منابع مشابه
The neurobiology of bipolar disorder.
The neurobiology of bipolar disorder is reviewed. Bipolar disorder is associated with alterations in central nervous system (CNS) function from the level of large-scale brain circuits to intracellular signal transduction mechanisms. Because of the broad spectrum over which these abnormalities appear, the causative effects are most likely present in the lowest common denominator of all of these ...
متن کاملIntegrated Neurobiology of Bipolar Disorder
From a neurobiological perspective there is no such thing as bipolar disorder. Rather, it is almost certainly the case that many somewhat similar, but subtly different, pathological conditions produce a disease state that we currently diagnose as bipolarity. This heterogeneity - reflected in the lack of synergy between our current diagnostic schema and our rapidly advancing scientific understan...
متن کاملThe Emerging Neurobiology of Bipolar Disorder
Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target. Second, facilitated by new technologies, it is increasingly ap...
متن کاملNeurobiology and Bipolar Disorder: beyond the Synapse*
Affective disorders have hitherto been explained in terms of neurotransmitter deficits or dysfunction. However, research in patients with bipolar disorder shows that, while neurotransmitter dysfunction is clearly important in the presentation of bipolar disorder, it is not the sole explanation for its etiology. Rather than all of the neurotransmitters being independently abnormal in bipolar dis...
متن کاملNeurobiology of Risk for Bipolar Disorder
Bipolar disorder (BD) is a chronic mental illness which follows a relapsing and remitting course and requires lifetime treatment. The lack of biological markers for BD is a major difficulty in clinical practice. Exploring multiple endophenotypes to fit in multivariate genetic models for BD is an important element in the process of finding tools to facilitate early diagnosis, early intervention,...
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ژورنال
عنوان ژورنال: Acta Neuropsychiatrica
سال: 2006
ISSN: 0924-2708,1601-5215
DOI: 10.1017/s0924270800032026